Modulation of stoichiometry of the sarcoplasmic reticulum calcium pump may enhance thermodynamic efficiency.
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چکیده
منابع مشابه
Invariance of stoichiometry of the sarcoplasmic reticulum calcium pump at physiological calcium concentrations--a reevaluation.
The decline of the transport ratio of the sarcoplasmic calcium pump observed in a recent study (A. Gafni and P. D. Boyer, Proc. Natl. Acad. Sci. USA 82, 89-101 [1985] ) results from the retardation of calcium oxalate precipitation at low calcium/protein ratios. The prevailing high internal calcium level supports a rapid calcium backflux and a compensatory ATP hydrolysis during net calcium uptak...
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Recovery of calcium transport and calcium-activated ATPase activity was studied in relation to the retention of protein components in sarcoplasmic reticulum reconstituted after solubilization with deoxycholate and centrifugation, followed by removal of the detergent from the supernatant by dialysis. Control sarcoplasmic reticulum was similarly treated except for omission of deoxycholate. Maximu...
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Illuminating sarcoplasmic reticulum calcium.
The bulk of the Ca 2 that activates contraction in the heart comes from the sarcoplasmic reticulum (SR). Calcium is released by the process of Ca -induced Ca release (CICR) in which the entry of a small amount of Ca across the cell membrane triggers the release of much more from the SR. This mechanism depends on the fact that Ca entry from the extracellular fluid (via the L-type Ca current) inc...
متن کاملSarcoplasmic Reticulum Calcium Uptake
To investigate the mechanism underlying postischemic cardiac dysfunction (myocardial stunning), contractility and adenine nucleotide metabolism were studied in three groups of isolated perfused rabbit hearts (control, ischemic, and reperfused), whereas Ca2` uptake by the sarcoplasmic reticulum (SR) was measured in homogenates obtained from them. The hearts were Langendorff-perfused under consta...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1985
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.82.1.98